Advancing Cancer Research with UID Technology

Innovative Tools for Identification, Monitoring, and Automation in Preclinical Oncology

Preclinical cancer research relies on precision, reproducibility, and humane practices. From tumor tracking to treatment toxicity, the quality of data depends not only on experimental design, but also on how that data is collected, managed, and interpreted. Unified Information Devices (UID) supports cancer researchers across all stages of preclinical research with a suite of integrated technologies that streamline study workflows, reduce stress on animals, and provide reliable and continuous data. UID’s solutions — including microchip-based identification, temperature monitoring, home cage activity tracking, and automated data capture systems — are designed to enhance study integrity and accelerate discoveries in cancer biology and therapeutics.

1. Improved Data Accuracy and Integrity

In oncology studies, especially those using xenograft or orthotopic models, even minor data inconsistencies can compromise entire trials. UID’s RFID-based animal identification and monitoring systems ensure:

Unambiguous animal tracking across timepoints and procedures
Hands-free data capture integrated with electronic calipers and balances
Automated workflows that reduce transcription errors and operator bias

Impact: Every measurement is accurately tied to the right subject — strengthening reproducibility, reducing rework, and supporting GLP compliance.

2. Enhanced Animal Welfare = Better Science

Handling stress can significantly affect tumor growth, immune response, and behavior in rodents. UID reduces stress and supports refinement with:

Subcutaneous temperature transponders for non-invasive health monitoring
Home Cage Monitoring (HCM) systems for undisturbed activity and temperature tracking
Minimal handling protocols thanks to contactless RFID scans

Impact: Healthier, more stable animals generate higher-quality, more reliable data — and studies better align with IACUC and AAALAC standards.

3. Real-Time, Longitudinal Monitoring

Cancer progression and treatment response are dynamic processes. UID’s Home Cage Monitoring and RFID temperature systems allow for:

Continuous 24/7 data collection
Early detection of distress, fever, or behavioral changes
Rich, time-stamped datasets for correlating physiology, activity, and treatment cycles

Impact: Researchers can identify inflection points earlier, refine endpoints, and build deeper insights into drug efficacy and tolerability.

4. Streamlined Study Operations

UID’s piSuite Oncology application consolidates tumor measurements, body weight, and animal ID into a single, automated platform. With seamless integration to RFID readers, electronic calipers, and balances, you get:

Efficient data collection across large cohorts
Standardized workflows across technicians and sites
Audit-ready reports for regulatory submissions

Impact: More data, fewer errors, and less time spent on manual entry or reconciliation — boosting throughput without sacrificing quality.

UID in Action: Supporting All Phases of Cancer Research

Research Phase	UID Value
Tumor Implantation	Confident animal tracking from Day 0
Treatment Evaluation	Hands-free, consistent tumor & weight measurements
Toxicity Monitoring	Continuous temperature & behavior tracking
Survival Studies	Improved humane endpoint detection
Data Analysis & Reporting	Integrated, standardized outputs for review and compliance

In oncology studies, accuracy, consistency, and animal well-being aren’t optional — they’re essential. UID provides an integrated toolkit that supports these priorities from engraftment to endpoint. With UID, cancer research teams can collect cleaner data, reduce animal stress, and confidently translate findings to the clinic.

Better data. Better decisions. Better science.

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UID Product Portfolio for Cancer Research Applications

Animal Identification and Tracking
UID’s high-quality RFID microchips provide permanent, reliable animal identification. Combined with cost-effective, durable handheld and automated readers, UID supports fast, error-free ID verification. Systems are software-agnostic and compatible with any LIMS or electronic data platform, facilitating seamless integration into existing workflows.
Temperature Monitoring
The UID Temperature Monitoring System uses implantable temperature transponders (±0.1°C accuracy) for stress-free, real-time monitoring. These dual-function RFID devices provide both animal ID and temperature data through a single, contactless scan.
Home Cage Monitoring
The UID Mouse Matrix allows for continuous, group-housed animal monitoring using RFID to track activity, location, and temperature. Data is automatically collected day and night, eliminating the need for manual intervention and enabling detection of subtle changes in physiology and behavior.
piSuite Tumor Measurement Application
UID’s piSuite Oncology software streamlines tumor measurement and weight tracking. It integrates with RFID readers, electronic calipers, and balances to automate data collection, reduce errors, and improve consistency. Ideal for xenograft, orthotopic, and PDX studies.

Featured Application: UID Technology in Toxicology Study of 2-DG and Ketogenic Diet

Study Overview

A preclinical study by Zielinski et al. (AACR-NCI-EORTC, 2023) investigated the safety and toxicological profile of combining a ketogenic diet (KD) with 2-deoxy-D-glucose (2-DG), a glycolysis inhibitor. While prior studies suggested synergy between KD and 2-DG in cancer therapy, this group observed a dose-dependent reduction in survival, highlighting critical safety concerns when combining metabolic interventions.

UID Technologies Used

UCT-2112 Temperature Transponders
Subcutaneously implanted RFID chips allowed for accurate, minimally invasive body temperature monitoring, which was critical for tracking hypothermia — a key symptom of treatment-related toxicity.
URH-1HP Handheld Reader
Enabled manual, contactless readings without disturbing animals, reducing handling stress and preserving natural physiological responses.
Mouse Matrix Home Cage Monitoring System
Allowed continuous, automated temperature monitoring in conscious, unrestrained mice. This real-time, hands-free system captured early signs of treatment-related decline, such as sedation and hypothermia, without the need for animal removal or repeated handling.

Key Findings from the Study

KD + 2-DG combination caused rapid, dose-dependent lethality, while 2-DG alone was well tolerated on a standard diet.
Hypothermia and sedation preceded mortality and were key early indicators of treatment-induced toxicity.
Significant thrombocytopenia and elevated LDH levels suggested systemic damage.
Histopathology confirmed interstitial pneumonia and hepatic degeneration, underscoring multi-organ impact.

Data

Scientific Value Delivered by UID

Research Objective	UID Contribution
Detect rapid onset of treatment toxicity	Real-time body temperature tracking exposed a lethal hypothermic response to 2-DG + KD
Minimize animal stress during measurement	Contactless scanning and HCM allowed for noninvasive, stress-free monitoring
Ensure reproducible physiological data	RFID-linked temperature tracking tied readings directly to individual animals
Monitor longitudinal trends in response	HCM enabled detection of time-dependent patterns associated with disease progression or treatment side effects
Support humane endpoints	Continuous data supported timely euthanasia decisions for animals experiencing severe toxicity

Conclusion

Citation

Featured Publications

Infectious Diseases

Goldin, Kerry, et al. “Enhanced encephalitic tropism of bovine H5N1 compared to the Vietnam H5N1 isolate in mice.” bioRxiv (2024): 2024-11.
Rao, Deepashri, et al. “Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.” (2024).
Lee, Hye-Lim, et al. “Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice.” Pharmacological Research 199 (2024): 107049.
Rao, Deepashri, et al. “CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice.” EBioMedicine 97 (2023).
Sriramula, Srinivas, et al. “Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection.” Cells 12.16 (2023): 2107.
Sriram, Srinivas, et al. “Long COVID in K18-hACE2 mice causes persistent brain inflammation and cognitive impairment.” (2022).
Leventhal, Shanna S., et al. “Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge.” EBioMedicine 82 (2022).
Wang, Tiecheng, et al. “Proteomic and metabolomic characterization of SARS-CoV-2-infected cynomolgus macaque at early stage.” Frontiers in Immunology 13 (2022): 954121.
Smeyne, Richard J., et al. “COVID‐19 infection enhances susceptibility to oxidative stress–induced parkinsonism.” Movement Disorders 37.7 (2022): 1394-1404.
Carossino, Mariano, et al. “Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression.” Biorxiv (2021): 2021-01.
Subramaniam, Saravanan, et al. “Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice.” Biorxiv (2021): 2021-08.

Metabolic Diseases and Thermoregulation

Sass, Frederike, et al. “NK2R control of energy expenditure and feeding to treat metabolic diseases.” Nature (2024): 1-14.
Park, Min Young, et al. “Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice.” Endocrinology 165.12 (2024): bqae141.
Serdan, Tamires Duarte Afonso, et al. “Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue.” bioRxiv (2024).
Basu, Rashmita, et al. “Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs.” Molecular Metabolism 84 (2024): 101951.
Jayne, Lorna, et al. “A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.” bioRxiv (2024).
Selescu, Tudor, et al. “TRPM8-dependent shaking in mammals and birds.” bioRxiv (2023): 2023-12.
Lin, Lin, et al. “Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood.” Cell metabolism 35.7 (2023): 1227-1241.
Min, Hyeon-Young, et al. “Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.” American Journal of Physiology-Endocrinology and Metabolism 323.3 (2022): E231-E241.

Animal welfare

Gaskill, Brianna N., et al. “Evaluation of Thermal Support during Anesthesia Induction on Body Temperature in C57BL/6 and Nude Mice.” Journal of the American Association for Laboratory Animal Science 63.3 (2024): 294-302.
Ferguson, Lindsey T., et al. “A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis.” Comparative Medicine 73.6 (2023): 446-460.
Zielinski, Rafal, et al. “Abstract B179: 2-Deoxy-D-glucose (2-DG) combination with ketogenic diet induces sedation and hypothermia in mice that becomes lethal.” Molecular Cancer Therapeutics 22.12_Supplement (2023): B179-B179.
Winn, Caroline B., et al. “Automated monitoring of respiratory rate as a novel humane endpoint: a refinement in mouse metastatic lung cancer models.” PLoS One 16.9 (2021): e0257694.

Sepsis

Carlin, Sean. STUDIES OF STREPTOZOTOCIN-INDUCED HYPERGLYCEMIA ON THE HOST RESPONSE TO SEPSIS. Diss. 2024.
Sharma, Neha, et al. “Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis.” Intensive Care Medicine Experimental 12.1 (2024): 28.
Ferguson, Lindsey T., et al. “A Novel Scoring System for Humane Endpoints in Mice with Cecal Ligation and Puncture-Induced Sepsis.” Comparative Medicine 73.6 (2023): 446-460.

Physiology

Bavis, Ryan W., et al. “Respiratory plasticity induced by chronic hyperoxia in juvenile and adult rats.” Respiratory Physiology & Neurobiology 333 (2025): 104386.
Hirschberg, Pamela M., et al. “Reducing neuronal nitric oxide synthase (nNOS) expression in the ventromedial hypothalamus (VMH) increases body weight and blood glucose levels while decreasing physical activity in female mice.” bioRxiv (2024): 2024-05.
Roths, Melissa, et al. “One day of environment-induced heat stress damages the murine myocardium.” American Journal of Physiology-Heart and Circulatory Physiology 327.4 (2024): H978-H988.
Blanton, Cynthia A., Hailey M. Streff, and Annette M. Gabaldón. “Effect of Dietary Enrichment with Hempseed (Cannabis sativa L.) on Blood Pressure Changes in Growing Mice between Ages of 5 and 30 Weeks.” Applied Sciences 14.17 (2024): 8006.

Pharmacology

Tagne, Alex Mabou, et al. “Δ9-Tetrahydrocannabinol Alleviates Hyperalgesia in a Humanized Mouse Model of Sickle Cell Disease.” The Journal of Pharmacology and Experimental Therapeutics 391.2 (2024): 174-181.
Blanton, Cynthia A., Hailey M. Streff, and Annette M. Gabaldón. “Effect of Dietary Enrichment with Hempseed (Cannabis sativa L.) on Blood Pressure Changes in Growing Mice between Ages of 5 and 30 Weeks.” Applied Sciences 14.17 (2024): 8006.
McKenna, Brandon A., et al. “A Pharmacokinetic and Analgesic Efficacy Study of Carprofen in Female CD1 Mice.” Journal of the American Association for Laboratory Animal Science 62.6 (2023): 545-552.
Rivera-Garcia, Maria T., Rizelle Mae Rose, and Adrianne R. Wilson-Poe. “High-CBD cannabis vapor attenuates opioid reward and partially modulates nociception in female rats.” Addiction neuroscience 5 (2023): 100050.
Lin, Lin, et al. “Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood.” Cell metabolism 35.7 (2023): 1227-1241.
Torrens, Alexa, et al. “Comparative pharmacokinetics of Δ9-tetrahydrocannabinol in adolescent and adult male and female rats.” Cannabis and cannabinoid research 7.6 (2022): 814-826.
Lee, Hye-Lim, et al. “Frequent low-dose Δ9-tetrahydrocannabinol in adolescence disrupts microglia homeostasis and disables responses to microbial infection and social stress in young adulthood.” Biological psychiatry 92.11 (2022): 845-860.
Ruiz, C. M., et al. “Pharmacokinetic and pharmacodynamic properties of aerosolized (“vaped”) THC in adolescent male and female rats.” Psychopharmacology 238 (2021): 3595-3605.

Nutrition

Zielinski, Rafal, et al. “Abstract B179: 2-Deoxy-D-glucose (2-DG) combination with ketogenic diet induces sedation and hypothermia in mice that becomes lethal.” Molecular Cancer Therapeutics 22.12_Supplement (2023): B179-B179.
Sparks, Chandler A., et al. “Dietary hempseed decreases femur maximum load in a young female C57BL/6 mouse model but does not influence bone mineral density or micro-architecture.” Nutrients 14.20 (2022): 4224.

Immumnology

Widmer, Katherine Marie. Use of a defined microbiota for maintenance of gnotobiotic SCID piglets. MS thesis. Iowa State University, 2024.
Ifediba, Marytheresa, et al. “Characterization of heterogeneous skin constructs for full thickness skin regeneration in murine wound models.” Tissue and Cell 88 (2024): 102403.
Xu, Thomas Tongzhu. Surface display of proteins on bone marrow-derived dendritic cells induces humoral immune responses and anaphylaxis. Harvard University, 2024.

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