Pharmacology Research
Advancements in pharmacology research demand innovative solutions to improve data accuracy, enhance efficiency, and ensure ethical animal research practices. Unified Information Devices (UID) technology is transforming preclinical pharmacology studies by enabling non-invasive, automated, and high-throughput monitoring of laboratory animals. The following content explores how UID technology supports drug development, safety pharmacology, and experimental therapeutics research.
Overview of UID Technology
UID offers cutting-edge solutions that integrate RFID-based animal identification, real-time physiological monitoring, and home cage monitoring systems. These technologies provide continuous, automated data collection, reducing human intervention while improving study reproducibility and compliance with the 3Rs (Replacement, Reduction, Refinement) principle.
Key UID Technologies:
- UID Temperature Transponders: Implantable microchips that enable real-time core body temperature monitoring.
- UID Home Cage Monitoring System: Non-invasive tracking of activity, circadian rhythms, and behavioral patterns.
- Automated Identification Systems: RFID-based tracking ensures precise animal identification in longitudinal studies.
Applications in Pharmacology Research
1. Drug Efficacy and Toxicology Studies
- Non-invasive physiological monitoring: Enables real-time assessment of drug effects on core body temperature, metabolism, and locomotion.
- Reduced handling stress: Automation minimizes human interference, reducing variability in pharmacokinetic and pharmacodynamic studies.
- Enhanced high-throughput screening: Enables continuous monitoring across multiple test subjects, optimizing data collection.
2. Safety Pharmacology
- Cardiovascular and metabolic assessments: Real-time tracking of temperature fluctuations can indicate drug-induced thermoregulatory changes.
- CNS drug testing: Behavioral and activity monitoring aids in evaluating neuroactive compounds, sedatives, and stimulants.
- Longitudinal studies with minimal disruption: Continuous data collection supports long-term safety assessments.
3. Disease Model Research and Therapeutics
- Metabolic Disorders: Supports research on diabetes, obesity, and thermoregulation by tracking temperature and activity patterns.
- Pain and Inflammation Studies: Temperature serves as a biomarker for inflammatory responses and analgesic effects.
- Neurodegenerative Disease Research: Identifies behavioral changes related to neurodegenerative disorders like Alzheimer’s and Parkinson’s.
4. Dosing and Pharmacokinetics
- Automated Subject Tracking: Ensures accurate linkage between individual animals and physiological data.
- Improved Reproducibility: Reduces variability in drug response data through continuous, standardized monitoring.
5. Ethical Considerations and Regulatory Compliance
- Refinement of Animal Research: Eliminates the need for invasive techniques, such as rectal probes, improving animal welfare.
- GLP and Regulatory Compliance: Ensures high data integrity, supporting regulatory submissions.
- Reduced Animal Use: Increases data collection efficiency per subject, aligning with the reduction principle of the 3Rs.
Conclusion
UID technology is revolutionizing pharmacology research by offering automated, non-invasive, and high-precision monitoring tools. By integrating RFID tracking, real-time temperature sensing, and home cage monitoring, UID enhances data accuracy, supports ethical research practices, and accelerates drug discovery. As pharmacology research continues to evolve, UID solutions will play a critical role in advancing preclinical studies while ensuring the highest standards of data integrity and animal welfare.
For more information on implementing UID technology in your research, contact us at info@uidevices.com.
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Featured Publications
Infectious Diseases
- Goldin, Kerry, et al. “Enhanced encephalitic tropism of bovine H5N1 compared to the Vietnam H5N1 isolate in mice.” bioRxiv (2024): 2024-11.
- Rao, Deepashri, et al. “Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection.” (2024).
- Lee, Hye-Lim, et al. “Frequent low-impact exposure to THC during adolescence causes persistent sexually dimorphic alterations in the response to viral infection in mice.” Pharmacological Research 199 (2024): 107049.
- Rao, Deepashri, et al. “CD8+ T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice.” EBioMedicine 97 (2023).
- Sriramula, Srinivas, et al. “Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection.” Cells 12.16 (2023): 2107.
- Sriram, Srinivas, et al. “Long COVID in K18-hACE2 mice causes persistent brain inflammation and cognitive impairment.” (2022).
- Leventhal, Shanna S., et al. “Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge.” EBioMedicine 82 (2022).
- Wang, Tiecheng, et al. “Proteomic and metabolomic characterization of SARS-CoV-2-infected cynomolgus macaque at early stage.” Frontiers in Immunology 13 (2022): 954121.
- Smeyne, Richard J., et al. “COVID‐19 infection enhances susceptibility to oxidative stress–induced parkinsonism.” Movement Disorders 37.7 (2022): 1394-1404.
- Carossino, Mariano, et al. “Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression.” Biorxiv (2021): 2021-01.
- Subramaniam, Saravanan, et al. “Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice.” Biorxiv (2021): 2021-08.
Metabolic Diseases and Thermoregulation
Animal welfare
Sepsis
Physiology
Pharmacology
Nutrition
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