Summary
This study compared wild-type and PAD4-deficient C57BL/6 mice in a fecal-induced peritonitis model of polymicrobial sepsis. PAD4 deficiency worsened survival in females and was associated with reduced early IL-10, greater lung neutrophil infiltration, and more severe lung injury; males fared worse than females, while antibiotics removed the survival differences. UID UCT-2112 temperature microchips supported physiological monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.