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Thesis Dissertation

The effect of the molecular weight of poly(I:C) on the development and behavior of offspring in the maternal immune activation model

Cmarkova, N 2023

Diploma thesis 2023

Summary

This rat study tested whether maternal immune activation with high-molecular-weight poly(I:C) produces depression-related changes in adolescent and adult offspring. Exposed offspring showed altered stress-coping behavior without reduced sucrose preference, alongside sex-dependent changes in serotonin-neuron firing and circulating cytokines that were strongest in males. UID UCT-2112 temperature microchips and a URH-1HP reader supported temperature monitoring and identification.

Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.

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