Summary
This dissertation showed that bone-marrow-derived dendritic cells can retain selected unprocessed serum proteins on their surface and present them to B cells. Transferring these cells into mice generated protein-specific antibodies, and later challenge caused severe anaphylaxis; robust responses required surface display, MHC class II presentation, germinal centers, and T follicular helper cells. UID UCT-2112 temperature microchips and a URH-1HP reader supported monitoring of the mouse responses.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.