Summary
This study tested whether repeatedly inducing a torpor-like state could alter aging in mice. Activating a defined anterior and ventral medial preoptic neuronal population produced hypothermia and lower metabolism, slowed epigenetic aging across multiple tissues, and improved healthspan; comparison experiments identified reduced core temperature, rather than caloric restriction or metabolic suppression alone, as the main mediator. UID UCT-2112 microchips measured core temperature.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.