Summary
This study identified muscle-derived Mimecan as a signal linking skeletal muscle, hypothalamic neurons, and brown adipose tissue in mice. Mimecan maintained primary cilia on MC4R-positive hypothalamic neurons and increased sympathetic drive to brown fat, supporting core-temperature regulation that weakens with age; restoring circulating Mimecan in old mice extended lifespan. UID UCT-2112 temperature microchips and a URH-1HP reader supported thermal measurements.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.