Summary
This mouse study examined behavior and brain changes after ten days of repeated oxycodone followed by spontaneous withdrawal. Oxycodone acutely increased movement and pain tolerance, but withdrawn mice later showed reduced social interaction and marble burying; medial prefrontal cortex tissue also had lower expression of Tcf7l2 and Klk6, genes involved in oligodendrocyte development and myelination. The findings link affective withdrawal signs with altered myelin-related gene expression.
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