Summary
This study tested THC for chronic pain in male sickle-cell mice and healthy controls. Acute THC dose-dependently reduced mechanical and cold hypersensitivity and increased tail-flick pain tolerance only in the sickle-cell model without changing anxiety or long-term memory; repeated treatment sustained mechanical relief but developed tolerance for cold pain. UID UCT-2112 temperature microchips and a URH-1HP reader supported physiological monitoring.
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