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Journal Article

Frequent Low-Dose Δ9-Tetrahydrocannabinol in Adolescence Disrupts Microglia Homeostasis and Disables Responses to Microbial Infection and Social Stress in Young Adulthood

Lee, H., et al. 2022

Biological Psychiatry

Summary

This study tested whether daily low-dose THC during adolescence persistently changes microglia in male and female mice. Exposure produced broad disruption of homeostatic and innate-immune gene programs in young adulthood and weakened microglial responses to bacterial endotoxin and repeated social stress; the effects receded with age and were prevented by blocking CB1 receptors. UID UCT-2112 temperature microchips and a URH-1HP reader supported monitoring and identification.

Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.

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