Summary
This study established an IL-23 minicircle model of psoriasis-like dermatitis in B10.RIII mice. A single injection produced sustained IL-23, dose-related ear inflammation, skin thickening, and recruitment of IL-17-producing immune cells over fourteen days; preventive anti-IL-23 treatment blocked the phenotype, and treatment after onset inhibited it in a dose-dependent manner. UID UC-2112 programmable microchips provided individual animal identification.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.