Summary
This study tested the metabolic role of fat-cell-derived FGF23 in diet-induced obesity. Deleting Fgf23 from adipocytes prevented high-fat-fed female mice, but not males, from gaining fat and body weight while preserving lean mass; it also limited dyslipidemia, hyperglycemia, and fatty liver and increased brown-fat thermogenic signaling without changing food intake. UID UCT-2112 temperature microchips supported thermal measurements.
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