Summary
This study explains how brown adipose tissue coordinates new blood vessels and sympathetic nerves during cold-induced thermogenesis. Adipocyte progenitors secreted SLIT3, which BMP1 split into two functional fragments: SLIT3-N promoted angiogenesis, while SLIT3-C acted through the newly identified PLXNA1 receptor to expand sympathetic innervation; both were required for an integrated thermogenic response. UID UCT-2112 microchips measured tissue temperature.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.