Summary
This study profiled lung and blood proteins and metabolites early after SARS-CoV-2 infection in cynomolgus macaques. Innate immunity, neutrophils, and platelet pathways were the main disruptions, while the pronounced neutrophilia, lymphopenia, and cytokine storm of severe human disease were muted, making the model more representative of moderate COVID-19 and useful for studying mechanisms and interventions. UID UCT-2112 temperature microchips supported clinical monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.