Summary
This study used genetically diverse Collaborative Cross mice to test whether host genetics help determine Crimean-Congo hemorrhagic fever severity. Infected lines reproduced outcomes ranging from mild or unrecognized infection to fatal hemorrhagic disease, and greater viral replication, tissue damage, and inflammation tracked with worse outcomes, closely paralleling human disease. UID UCT-2112 temperature microchips provided continuous physiological monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.