Summary
This study mapped SARS-CoV-2 infection over time in K18-hACE2 mice to determine what drives lethal disease. Rapid decline and death consistently coincided with viral entry into the brain and direct neuronal injury, apparently beginning in the olfactory bulb without detectable viremia; viral tropism also did not strictly follow detectable hACE2 expression. UID UCT-2112 temperature microchips supported continuous physiological monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.