Reducing neuronal nitric oxide synthase (nNOS) expression in the ventromedial hypothalamus (VMH) increases body weight and blood glucose levels while decreasing physical activity in female mice

Summary

This study reduced neuronal nitric oxide synthase expression in the ventromedial hypothalamus of female mice to test a proposed energy-balance circuit. Contrary to the original hypothesis, temperature and thermogenic protein levels did not change, but body weight and adiposity rose by about 30% over two weeks as blood glucose increased and activity fell. UID UCT-2112 temperature microchips, a URH-1HP reader, and a UBS-200L base station supported monitoring.

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