Summary
This mouse study examined short, repeated exposure to fine particulate air pollution and extreme heat in a model of early-onset Alzheimer's disease. The combined stressors disrupted brain energy metabolism, mitochondrial respiration, hippocampal signaling, intestinal permeability, the gut microbiome, and immune pathways, but did not accelerate cognitive decline in young asymptomatic mice. UID UCT-2112 temperature microchips and a URH-1HP reader supported thermal monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.