Summary
This study used longitudinal MRI and histology to isolate the effects of cerebral amyloid angiopathy in a transgenic rat model. Small thalamic microbleeds appeared by six months and preceded a distinct pattern of white-matter loss at nine and eleven months; pathology showed myelin loss near occluded, calcified vessels where amyloid deposition was greatest. UID UCT-2112 temperature microchips supported longitudinal animal monitoring.
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