Summary
This study developed selective, long-acting neurokinin 2 receptor agonists that combine appetite suppression with increased energy expenditure. In mice the compounds reduced food intake, raised expenditure, improved insulin sensitivity, and caused weight loss without aversive behavior; in obese diabetic macaques they also lowered weight, glucose, triglycerides, cholesterol, and insulin resistance. UID UCT-2112 temperature microchips measured thermogenic responses.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.