Summary
This dissertation maps hypothalamic circuits that regulate energy expenditure and weight loss in diet-induced obese mice. Activating ventromedial hypothalamic and caudal preoptic neuron populations increased thermogenesis or reduced food intake, lowering body weight and adipose mass through separate pathways; sequencing also identified obesity-responsive neuronal subtypes. UID UCT-2112 temperature microchips and a URH-1HP reader supported body-temperature measurements and animal identification.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.