Summary
This mouse study traced a hypothalamic circuit that links ventromedial hypothalamic neurons to the preoptic area and peripheral tissue thermogenesis. Activating SF1 neurons, including a PACAP-expressing subset, increased energy expenditure and reduced body weight and adiposity in diet-induced obesity, identifying a pathway that may help limit rebound weight gain. Implantable UID temperature microchips and a URH-1HP reader recorded physiological temperature changes.
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