Summary
This mouse study identified the ubiquitin ligase Rlim as a circadian regulator of feeding and thermogenesis. Mice lacking Rlim were lean and resistant to diet-induced obesity because they ate less and generated more brown-fat heat; suprachiasmatic GABA neurons separated these functions, with Rlim in RIP-Cre neurons governing daily thermogenic rhythms and Rlim in VIP neurons controlling feeding rhythms. UID UCT-2112 microchips and a URH-1HP reader measured temperature.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.