Summary
This study compared aerosol infection with a 2024 bovine H5N1 isolate and a 2004 human H5N1 isolate in C57BL/6J mice. Both strains were lethal, but the older isolate largely remained in the respiratory tract while the bovine strain replicated throughout the brain and produced a distinct central nervous system cytokine response, with viral evidence also found in the retina and inner ear. UID UCT-2112 temperature microchips supported physiological monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.