Summary
This study used immunocompetent mice to determine how cellular immunity controls acute Crimean-Congo hemorrhagic fever virus infection. CD8-positive T cells rapidly acquired antiviral cytokine and degranulation responses, targeted defined epitopes in the viral Gc protein, and were essential for efficient control; mice lacking interferon gamma developed worse disease and higher viral loads. UID UCT-2112 temperature microchips supported continuous disease monitoring.
Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.