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Long COVID in K18-hACE2 mice causes persistent brain inflammation and cognitive impairment

Sriramula, S., et al. 2022

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Summary

This study established a mouse model of persistent neurologic effects after mild SARS-CoV-2 infection. Recovered male and female K18-hACE2 mice developed lung fibrosis, elevated kinin B1 receptor and inflammatory markers in the lungs and brain, greater anxiety, and less exploratory behavior, implicating sustained B1-receptor signaling in long-term neuroinflammation and cognitive symptoms. UID UCT-2112 temperature microchips supported infection and recovery monitoring.

Summary written by UID from the published work. Read the original publication for the authors' abstract and full methods.

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